His current research is both basic and clinical and centers on the effectiveness of yoga and meditation practices; he is currently conducting clinical research trials evaluating a yoga treatment for insomnia funded by the National Center for Complementary and Alternative Medicine of the National Institutes of Health.  In active collaboration with the Kripalu Center for Yoga and Health, he directs their research team and is involved in a current project that evaluates the benefits of yoga for professional musicians, among others.  He has additional collaborations examining the role of yoga as a therapeutic treatment for conditions such as diabetes, stress, and cardiovascular disease.

Dr. Khalsa has established relationships with fellow yoga researchers in the US as well as in Europe and India, where he routinely attends and presents at international yoga research conferences.  He also teaches Mind Body Medicine at Harvard Medical School, which provides medical students with direct exposure to Kundalini Yoga.